医疗辅助生殖与产后抑郁症之间的关联:基于登记的队列研究
Sofie Egsgaard1,2, Mette Bliddal2,3, Line Riis Jølving4
1Research Unit of Child and Adolescent Psychiatry, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
概括
通过医疗辅助生殖 (MAR) 怀孕的女性与自发怀孕的女性相比,患产后抑郁症 (PPD) 的风险较低. 这一发现表明,对父母的心理准备可能会影响MAR用户的PPD风险.
科学领域:
- 生殖医学 生殖医学
- 心理健康 心理健康
- 围产阶段精神病学 围产阶段精神病学
背景情况:
- 在全球范围内,医疗辅助生殖 (MAR) 的使用正在增加.
- 接受MAR的女性的心理健康结果各不相同.
- 产后抑郁症 (PPD) 是分娩后的一个重大问题.
研究的目的:
- 调查医疗辅助生殖 (MAR) 怀孕与产后抑郁症 (PPD) 风险之间的关联.
- 为了比较通过MAR怀孕的母亲与自发怀孕的母亲的PPD风险.
主要方法:
- 在丹麦进行的一项基于登记册的研究.
- 包括125,870名在2015-2019年期间拥有PPD查记录的母亲.
- 连接国家卫生登记处以识别MAR怀孕和PPD (爱丁堡产后抑郁量表得分≥11).
主要成果:
- 这项研究包括10,977名MAR怀孕的母亲和114,893名自发怀孕的母亲.
- 在MAR怀孕的母亲中观察到较低的PPD风险 (aRR 0.87,95%CI [0.80-0.93]).
- 根据MAR类型,持续时间和适应症,PPD风险呈现小幅变化.
结论:
- 通过MAR怀孕的母亲与自发怀孕的母亲相比,PPD的风险较低.
- 观察到的效果很可能是由于MAR寻求女性对育儿的心理准备,而不是MAR本身.
- 在MAR使用者中,PPD风险可能会受到特定治疗和寻求MAR的原因的影响.
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