减少Flavonifractor plautii及其产物 - - 植物素,使湿体构成的个体容易发生代谢障碍
Lingru Li1, Tianxing Li1,2, Xue Liang1
1National Institute of Traditional Chinese Medicine Constitution and Preventive Treatment of Diseases, Beijing University of Chinese Medicine, Beijing, China.
湿体构成 (PDC) 个体表现出肠道细菌的改变和较低的花素,增加代谢障碍的风险. 补充这种化合物和细菌可以预防和治疗这些疾病.
科学领域:
- 综合医学是一个整体的医学.
- 肠道微生物组研究研究
- 代谢障碍的机制 代谢障碍的机制
背景情况:
- 传统中国医学 (TCM) 将液湿度构成 (PDC) 与代谢障碍联系起来.
- PDC个体表现出代谢基因表达变化,但机制尚不清楚.
- 肠道微生物群是理解TCM原则的潜在关键.
研究的目的:
- 为了研究患有PDC的个体的肠道微生物群和血清代谢物概况.
- 在PDC的背景下,阐明植物素和Flavonifractor plautii在代谢障碍中的作用.
- 探索F. plautii和植物素在代谢调节中的治疗潜力.
主要方法:
- 在PDC和对照组中分析肠道微生物群和血清代谢物.
- 在PDC得分,植物素水平和代谢参数之间的相关性研究.
- 在体内实验涉及便微生物群移植和补充在小鼠模型.
- 对植物素与肝脏PPARα相互作用的机制研究.
主要成果:
- PDC个体表现出明显的肠道微生物群和血清代谢物概况,特别是减少了植物素.
- 弗拉沃尼骨折分子 Plautii 合成了植物素,它与 PDC 评分有负相关性.
- 在正常的代谢指数的PDC受试者中,降低F. plautii和植物素水平预测了加速的代谢障碍的发展.
- 补充F. plautii和植物素通过激活PPARα通过肠肝轴改善了代谢障碍.
结论:
- 减少的F. plautii和植物素有助于PDC个体的代谢障碍易感性.
- 植物素直接激活肝脏PPARα,调节葡萄糖和脂质代谢.
- 诊断PDC可以识别有风险的个体,用于早期代谢障碍预防和提前TCM整合.
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