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减少Flavonifractor plautii及其产物 - - 植物素,使湿体构成的个体容易发生代谢障碍.

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  • 1National Institute of Traditional Chinese Medicine Constitution and Preventive Treatment of Diseases, Beijing University of Chinese Medicine, Beijing, China.

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湿体构成 (PDC) 个体表现出肠道细菌的改变和较低的花素,增加代谢障碍的风险. 补充这种化合物和细菌可以预防和治疗这些疾病.

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科学领域:

  • 综合医学是一个整体的医学.
  • 肠道微生物组研究研究
  • 代谢障碍的机制 代谢障碍的机制

背景情况:

  • 传统中国医学 (TCM) 将液湿度构成 (PDC) 与代谢障碍联系起来.
  • PDC个体表现出代谢基因表达变化,但机制尚不清楚.
  • 肠道微生物群是理解TCM原则的潜在关键.

研究的目的:

  • 为了研究患有PDC的个体的肠道微生物群和血清代谢物概况.
  • 在PDC的背景下,阐明植物素和Flavonifractor plautii在代谢障碍中的作用.
  • 探索F. plautii和植物素在代谢调节中的治疗潜力.

主要方法:

  • 在PDC和对照组中分析肠道微生物群和血清代谢物.
  • 在PDC得分,植物素水平和代谢参数之间的相关性研究.
  • 在体内实验涉及便微生物群移植和补充在小鼠模型.
  • 对植物素与肝脏PPARα相互作用的机制研究.

主要成果:

  • PDC个体表现出明显的肠道微生物群和血清代谢物概况,特别是减少了植物素.
  • 弗拉沃尼骨折分子 Plautii 合成了植物素,它与 PDC 评分有负相关性.
  • 在正常的代谢指数的PDC受试者中,降低F. plautii和植物素水平预测了加速的代谢障碍的发展.
  • 补充F. plautii和植物素通过激活PPARα通过肠肝轴改善了代谢障碍.

结论:

  • 减少的F. plautii和植物素有助于PDC个体的代谢障碍易感性.
  • 植物素直接激活肝脏PPARα,调节葡萄糖和脂质代谢.
  • 诊断PDC可以识别有风险的个体,用于早期代谢障碍预防和提前TCM整合.