大型抑郁症中视觉网络过度集成及其与基因表达特征相关
Mingrui Zhu1,2, Yifan Chen3,4, Junjie Zheng4,5
1Department of Neurology, Liaoning Provincial People's Hospital, Shenyang, Liaoning, China.
Translational psychiatry
|March 18, 2025
概括
大型抑郁症 (MDD) 显示大脑网络连接的改变,特别是在视觉网络. 这些变化与基因表达和症状严重程度有关,为MDD提供了洞察力.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 遗传学 是一个遗传学.
背景情况:
- 大型抑郁症 (MDD) 与异常的大脑网络连接有关.
- 网络模块互动障碍的具体性质及其在MDD中的遗传基础仍然不清楚.
研究的目的:
- 调查大脑网络模块化交互功能障碍在MDD中的特征.
- 探索这些网络变化,临床症状和基因表达特征之间的关联.
主要方法:
- 在262名MDD患者和297名健康对照中利用休息状态功能磁共振成像 (R-fMRI).
- 使用参与系数 (PC) 评估大脑网络集成,并分析了模块内和模块间的连接.
- 与临床症状严重程度和阿伦人类大脑图谱 (AHBA) 的死后基因表达数据相关联的图形理论措施.
主要成果:
- 与对照组相比,MDD患者表现出改变的系统功能连接.
- 观察到视觉网络 (VIS) 内PC增加,与更高阶和边缘网络的连接增加,但VIS内和与感觉运动网络 (SMN) 的连接性减少.
- 跨VIS连接与抑郁症严重程度有正相关,而内VIS连接与抑郁症和认知功能障碍有负相关. 基因表达特征解释了21-23.5%的网络失联差异.
结论:
- MDD的特点是模块化连接组功能障碍,特别是涉及视觉网络.
- 这些网络变化与特定的基因表达模式 (跨突触信号传输,离子传输) 和临床症状学有关.
- 研究结果提供了对MDD的神经生物学见解,可能为临床管理和治疗策略提供信息.
更多相关视频
07:58Behavioral and Network Pharmacology-Based Analyses for the Traditional Mongolian Medicine Zadi-5 in a Rat Model of Depression
Published on: February 24, 2023
438
04:33Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
Published on: April 26, 2024
568
相关概念视频
Long-term Depression
27.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
27.3K
Long-term Depression
2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
2.6K
Depression: Overview
1.2K
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
1.2K
Antidepressant Drugs: Overview
2.1K
Antidepressant drugs are a class of medications primarily used for treating various mood disorders, including major depression, anxiety disorders, and other related conditions. These medicines work by modulating the neurotransmitter balance within the brain, alleviating depressive symptoms. Antidepressants can be broadly categorized into several groups according to their mechanism of action and chemical structure: Selective Serotonin Reuptake Inhibitors (SSRIs), Serotonin-Norepinephrine...
2.1K
Human Genetics
2.0K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
The complex relationship between genetics and psychology is observable through common biological components such...
2.0K
Depressive Disorders: Etiology
887
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
887
