孕期高糖饮食调解了子女中腹腔动脉中的血管超收缩性
Xinying Liu1, Meng Liu2, Chunxia Wang1
1Department of Obstetrics, Affiliated Hospital of Jining Medical University, 272001, Jining, China.
Scientific reports
|March 18, 2025
概括
在大鼠中产前高糖饮食导致成年后代的血管收缩增加. 这与改变的Wnt5a信号,水平和减少的氧化功能有关,影响血管健康.
科学领域:
- 心血管生物学 心血管生物学
- 发展规划 发展规划
- 血管生理学 血管生理学
背景情况:
- 产前接触高糖饮食可以为后代的晚年血管疾病编程后代.
- 了解母亲饮食影响胎儿血管发育的机制对于预防策略至关重要.
研究的目的:
- 调查产前高糖饮食对成年后代抵抗动脉血管活性的影响.
- 阐明产前高糖饮食诱导的血管功能障碍背后的分子通路和细胞变化.
主要方法:
- 在整个孕期内,孕妇大鼠被食正常或高糖饮食.
- 从成年后代的中腔动脉中分析了血管功能,基因表达 (RNA-seq) 和蛋白质水平.
- 评估了关键的信号通路,包括Wnt5a,蛋白激酶C (PKC) 和内醇1,4,5-三酸盐受体 (IP3R).
主要成果:
- 高糖饮食母的后代表现出更厚的光滑肌肉层和中腔动脉中线粒体胀.
- 产前高糖饮食导致烯和5-二胺对血管收缩的增强.
- 观察到CYRAB和HSPE1的上调和APCDD1的下调,同时增加了细胞内水平.
- 在高糖组中观察到Wnt5a,PKC或IP3R通路的抑制,以及内皮氧化 (NO) 功能受损.
结论:
- 产前高糖饮食会诱导成年后代中腔动脉的高血管收缩.
- 这种血管功能障碍是由增强的Wnt5a-PKC/IP3R-Ca2+通路介导的.
- 缺陷的内皮氧化功能进一步导致观察到的血管异常.
更多相关视频
10:31An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
10.6K
05:44Author Spotlight: Collecting the Brain and Serum from the Same Mice Fetus to Study Brain Tumor Development
Published on: May 17, 2024
495
相关概念视频
01:27Glucose Transporters
22.3K
Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
22.3K
01:20Pathophysiology of Diabetes
837
Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
837
01:22Diabetes Mellitus: Type 2 and Gestational
2.1K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.1K