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Updated: May 21, 2025

Screening Traditional Chinese Medicine Compounds for Inhibiting UCHL3 Activity Based on Molecular Docking and Deubiquitinating Enzyme Probe Technology
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分子剂可以抑制二维基酶活性和炎症信号传递

Francesca Chandler1, Poli Adi Narayana Reddy2, Smita Bhutda3

  • 1Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

Nature structural & molecular biology
|March 18, 2025
PubMed
概括

研究人员开发了新的BRISC分子剂 (BLUEs),通过稳定自身抑制的二分体,选择性地抑制BRISC复合物. 这种方法提供了针对炎症信号通路和开发I型干扰素介导疾病治疗方法的新策略.

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