在成年人中,相对脂肪量与胆结石风险之间的关联
Jianjun Wang1,2, Wei He3, Ruizi Shi1
1Department of Hepatobiliary Surgery, School of Medicine, Mianyang Central Hospital, University of Electronic Science and Technology of China, Mianyang, 621000, China.
Scientific reports
|March 18, 2025
概括
相对脂肪量 (RFM) 是比BMI更好的胆结石风险指标. 较高的RFM水平与增加的GS患病率和早期手术年龄相关.
科学领域:
- 肥胖研究的研究.
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 胆结石 (GS) 与肥胖密切相关,通常通过身体质量指数 (BMI) 来评估.
- 体重指数 (BMI) 在反映真正的肥胖症方面存在局限性,因为它无法解释脂肪分布,特别是性别之间的差异.
- 相对脂肪量 (RFM) 是一个新兴的人类指数,可以更好地估计整体和腹部肥胖,并与肥胖相关的疾病有关.
研究的目的:
- 调查相对脂肪量 (RFM) 与患胆结石 (GS) 的风险之间的关联.
- 为了检查RFM和患者进行首次GS手术的年龄之间的关系.
- 与BMI相比,评估RFM对GS风险的预测能力.
主要方法:
- 利用了来自国家健康和营养检查调查 (2017-2020) 的数据,其中包括7978名成年人 (≥20岁).
- 采用后勤回归和剂量反应曲线来分析RFM与GS患病率和第一次GS手术时的年龄之间的关系.
- 进行子组分析并使用接收器运行特征 (ROC) 曲线来评估RFM与BMI的预测值.
主要成果:
- 每增加1个单位的RFM与GS流行率上升9%相关 (OR:1.09,95%CI:1.07-1.11),表明正面的,非线性相关性.
- 在整个人口亚组中,RFM和GS患病率之间的正相关性是一致的.
- 与BMI相比,RFM显示GS患病率的预测值优于GS患病率,GS患病率 (40.99) 和第一次手术时的年龄 (30.99) 都确定了值.
结论:
- 相对脂肪量 (RFM) 与胆结石 (GS) 患病率和风险显著相关.
- 较高的RFM水平预测了患GS的风险增加和第一次GS手术的早期年龄.
- 与传统的BMI测量相比,RFM可以更有效地预测GS风险.
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