在血液病患者中使用Ceftazidime-avibactam:单中心经验
Aysun Halacoglu1, Mustafa Koroglu2, Mehmet Ozen2
1School of Medicine, Department of Hematology and Bone Marrow Transplantation Unit, Istinye University, Medicalpark Gaziosmanpasa Hospital, Istanbul, Turkey. aysunhalacoglu@hotmail.com.
概括
塞法胺-阿维巴克坦在接受干细胞移植或化疗的血液病患者中显示出有效性. 关键的死亡指标包括年龄,肺炎,机械通风需求和中性质衰竭的持续时间.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 血液病患者,特别是那些接受造血干细胞移植 (HSCT) 或化疗的患者,面临严重感染的高风险.
- 抗菌素耐药性在管理这些脆弱的患者群体方面构成了重大挑战.
研究的目的:
- 为了评估ceftazidime-avibactam的有效性,这是一个塞法洛斯波林/β-乳糖酶抑制剂组合,在血液病患者.
- 为了确定与这种患者队列中死亡率相关的风险因素.
主要方法:
- 80名血液病患者的回顾性评估,他们接受了至少3天的Ceftazidime-avibactam治疗.
- 收集的数据包括人口统计数据,感染类型,住院时间,中性粒细胞计数,中性粒细胞衰竭时间,先前接触过抗生素,查尔森并发症指数和机械通风状态.
主要成果:
- 该研究包括了平均年龄为50岁的患者,其中许多人接受过高血压治疗 (42.5%全源,21.25%自身) 或接受过化疗 (36.25%).
- 超过一半 (57.5%) 的患者在感染后28天内死亡.
- 28天死亡率的独立风险因素包括较长的平均年龄,肺炎,需要机械通风和长时间的中性质衰竭持续时间.
结论:
- 血液病患者感染的死亡率仍然很高,特别是那些由耐药微生物引起的感染.
- 年龄,肺炎,机械通风需求和中性质衰竭的持续时间是死亡率的关键指标.
- 塞法胺-阿维巴克坦是一种可行的治疗选择,其改善的结果可能与需要机械通风之前更早的服用有关.
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