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成年人体体重指数,体重增加和癌症风险:基于人口的队列研究

Marko Mandic^1,2, Fatemeh Safizadeh^1,2, Ben Schöttker¹

¹Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 581, 69120, Heidelberg, Germany.

|March 18, 2025

概括

成年人体重增加是与肥胖相关的癌症风险的更强有力的预测因素,而不是单个时间点的体重指数 (BMI). 超重影响癌症风险在晚年成年期更显著.

科学领域:

流行病学流行病学
公共卫生公共卫生
在瘤学瘤学.

背景情况:

超重与癌症风险之间的联系已经确立,但其在一生中的演变仍然不清楚.
调查不同成年年龄体重和体重增加对癌症风险的影响对公共卫生至关重要.
了解这些关联可以为有针对性的癌症预防策略提供信息.

研究的目的:

检查各种成人年龄段的体重指数 (BMI) 和成人体重增加与与肥胖相关的癌症风险之间的关联.
为了确定超重暴露的时间是否会影响癌症风险.
为了比较BMI在不同生命阶段的预测能力与癌症发病率的累积体重增加.

主要方法:

利用了来自德国人口基队列研究 (N=9,218) 的数据,该研究涉及50至75岁的参与者.
在20岁,30岁,40岁,50岁和基线时评估的体重指数 (BMI),以及自20岁以来的体重变化.
采用多变量Cox模型来估计与肥胖相关的癌症的危险比率 (HRs),平均随访时间为17.1年.

主要成果:

在早期/中年成人期超重和肥胖没有显示出显著的癌症风险关联.
在50岁及以上的超重和肥胖患者中观察到显著的积极关联.
成年人体重增加与癌症风险有很强的关联,在调整基线BMI后仍然存在;基线BMI的关联减少.

结论:

超重可能会对整个生命中的癌症风险产生不同的影响,在晚年成年时可能会产生更大的影响.
成年人体重增加似乎是一个更强大的肥胖相关的癌症风险指标比BMI在一个时间点.
这些发现强调了在癌症风险评估中考虑体重轨迹的重要性,而不是单个BMI测量.

关键词:

乳腺癌乳腺癌乳腺癌癌症癌症癌症癌症结肠直肠癌是一种癌症.体重过重是因为超重.肥胖问题肥胖问题体重过重的情况体重增加体重增加

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