老年人中潜伏结核病感染的风险因素集群:中国东部基于人口的横截面研究
Zhenguo Zhu1, Wei Shen1, Jiajun Hu1
1County Health Inspection Office, Deqing County Center for Disease Prevention and Control, Deqing county, 313200, Zhejiang province, China.
BMC infectious diseases
|March 18, 2025
概括
在德庆老年人肺结核查发现,潜在肺结核感染 (LTBI) 率为7.34%,男性和老年人更高. 年龄和酒精消费被确定为LTBI集群风险因素.
科学领域:
- 公共卫生 公共卫生
- 流行病学 流行病学
- 传染病控制和控制传染病
背景情况:
- 结核病 (TB) 仍然是一个重大的全球卫生挑战.
- 大规模查对于检测隐藏的结核病例和潜伏结核病感染 (LTBI) 至关重要.
- 本研究重点关注德清县老年人口中LTBI患病率和风险因素.
研究的目的:
- 用干扰素马释放试验 (IGRA) 评估德庆县老年人中LTBI的流行率.
- 确定与LTBI相关的人口和生活方式风险因素.
- 探索老年人群中LTBI和相关风险因素的空间聚类.
主要方法:
- 一项涉及德清县26234名老年居民 (≥60岁) 的横截面研究.
- IFN-γ释放试验 (IGRA) 用于LTBI查.
- 使用空间自相关分析和后勤回归来确定LTBI集群和风险因素.
主要成果:
- 整体LTBI的患病率为7.34% (1,878例).
- 在男性,70岁以上的个人,吸烟者和酒精消费者中观察到更高的LTBI患病率.
- 年龄 (70-79岁) 和酒精消费被确定为LTBI集群风险因素,而低BMI和识字是保护性的.
结论:
- 该研究强调,德庆县的老年男性和特定风险群体中存在相当大的LTBI负担.
- 确定年龄和酒精消费是关键的聚类因素,使得有针对性的结核病预防战略成为可能.
- 在高风险村庄的干预可以改善老年人群的结核病控制工作.
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