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在Anopheles gambiae复合体中,口味受体的分子演变

Zachary R Popkin-Hall^1,2, Michel A Slotman^3,4

¹Department of Entomology, Texas A&M University, College Station, TX, USA. zach_popkin-hall@med.unc.edu.

BMC ecology and evolution

|March 18, 2025

概括

阿诺菲莱斯蚊子中的口味受体 (Grs) 显示出选择的迹象,其中一些可能影响疟疾载体的宿主偏好和糖检测,如阿诺菲莱斯gambiae.

科学领域:

分子进化分子进化
基因组学就是基因组学.
载体生物学载体生物学

背景情况:

复杂的蚊子传播疟疾. 虫虫复杂的蚊子传播疟疾.
人类爱好物种 (An. 科鲁齐,一个. 冈比亚国家航空公司,安. 阿拉比尼斯 (Arabiensis) 与动物爱好型的阿拉比尼斯 (An. 四角形. 四角形. 四角形.
寻找宿主的行为依赖于化学感知基因家族:Ors,Irs,Grs和Obps.

研究的目的:

分析Anopheles gambiae复合体中味觉受体 (Grs) 的分子进化模式.
在人性化的蚊子物种中,在积极选择下识别Grs.

主要方法:

使用麦当劳-克雷特曼测试检测阳性和净化选择.
使用DH测试来识别潜在的选择性扫描.
分析了与进化模式一起的转录基因数据.

主要成果:

确定了16个具有潜在积极选择的Grs,包括4个糖受体和2个具有未知的配体.
在潜在的净化选择下发现了12个Gr,以及12个潜在的选择性扫描 (包括CO2受体Gr24).
在沿海物种An.中检测到阳性和净化选择. 梅拉斯和一个. 这是MERUS.MERUS.

结论:

四个Gr是Anopheles属中脊椎动物宿主偏好进化的候选基因.
糖受体可能在一些Anopheles物种最近的适应中发挥作用.
由于其在很大程度上未知的功能,需要进一步对Grs进行表征.

关键词:

亚诺菲莱斯甘比亚 (Anopheles gambiae) 是一种在非洲的动物.化学感知基因是化学感知基因.味觉受体是一种味觉受体.主机差异化主机差异化分子进化是分子进化的过程.

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