在长期治疗直肠癌的新辅助疗法之前,口腔口腔与无口腔口腔相比
Gustav Sandén1, Petrus Vinnars1, Ingrid Ljuslinder2
1Department of Diagnostics and Intervention, Surgery, Umeå University, Umeå, Sweden.
BJS open
|March 18, 2025
概括
在接受新辅助疗法的直肠癌患者中,预防性静脉栓增加并发症并延迟治疗. 与前期治疗相比,这些口腔与更高的并发症率和延迟开始治疗有关.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 胃肠病学 胃肠病学
背景情况:
- 大肠阻塞是接受新辅助治疗的直肠癌患者的潜在并发症.
- 预防性失效口腔可能会防止阻塞,但可能会引发其自身的并发症.
- 这项研究比较了在新辅助疗法之前有或没有预防性口腔瘤的直肠癌患者的并发症率.
研究的目的:
- 为了研究长期接受新辅助疗法的直肠癌患者的并发症率.
- 为了比较接受预防性静脉口腔支架的患者与没有接受这种支架的患者之间的结果.
- 评估预防性口腔对治疗时间和存活率的影响.
主要方法:
- 在瑞典从2007年到2022年对105名直肠癌患者的回顾性分析.
- 排除具有紧急静脉栓症指示或非治愈性新辅助治疗计划的患者.
- 主要结局:诊断和切除之间的并发症;次要:切除后30天的并发症,治疗时间和整体生存期. 使用了多变量回归分析.
主要成果:
- 与没有 (29.6%) 相比,患有预防性静脉口腔 (22.9%) 的患者在切除前的并发症率显著更高 (75.0%).
- 胃口外科手术本身导致了相当多的并发症,任何并发症的调整后OR为6.71.
- 静脉口腔组经历了延迟的新辅助治疗 (21天),但在30天的切除后并发症或调整后的整体存活率上没有显著差异.
结论:
- 在接受新辅助疗法的无症状直肠癌患者中,预防性静脉口腔与增加的并发症和治疗延迟有关.
- 在这种情况下,预防性口腔的好处并不超过增加的风险和治疗延迟.
- 在新辅助性直肠癌治疗方案中实施预防性口腔口腔前,需要仔细考虑.
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