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细菌细菌通过依赖SigB的途径确保高质量的子在与沙门氏菌Typhimurium的竞争中

Eli Podnar¹, Kristina Dendinovic^1,2, Tjaša Danevčič¹

¹Department of Microbiology, Biotechnical Faculty, University of Ljubljana, Ljubljana 1000, Slovenia.

The ISME journal

|March 18, 2025

概括

有益细菌和病原体之间的相互作用至关重要. 在与沙门氏菌 (Salmonella Typhimurium) 竞争时,Bacillus subtilis的分泌物减少,由西格玛因子B (SigB) 的压力反应介导.

科学领域:

微生物学微生物学
细菌相互作用细菌相互作用
益生菌和病原体

背景情况:

有益细菌和病原体之间的相互作用尚未得到充分理解.
像Bacillus subtilis这样的益生菌对健康有好处,但它们与病原体的相互作用需要进一步研究.

研究的目的:

为了研究益生菌 Bacillus subtilis PS-216 和病原体 Salmonella Typhimurium SL1344.4 之间的相互作用.
阐明在与沙门氏菌Typhimurium竞争期间,细菌细菌的分泌障碍背后的机制.

主要方法:

在缺乏营养的介质中进行共同培养实验.
使用Bacillus subtilis的ΔsigB突变物进行遗传分析.
调查沙门氏菌Typhimurium第六类分泌系统的作用.

主要成果:

在与沙门氏菌 (Salmonella Typhimurium) 竞争时,细菌细菌 (Bacillus subtilis) 的化显著受损.
运动障碍取决于Bacillus subtilis中西格玛因子B (SigB) 介导的一般应激反应.
细胞与细胞的接触,涉及沙门氏菌Typhimurium类型VI分泌系统,对于观察到的Bacillus subtilis分泌的减少至关重要.
细菌细菌通过SigB依赖反应优先考虑子质量而不是数量.

结论:

细菌细菌中的西格玛因子B (SigB) 途径调解了对沙门氏菌Typhimurium竞争的反应,导致胞减少.
沙门氏菌Typhimurium利用其VI型分泌系统通过直接接触来抑制细菌细菌的分泌.
细菌细菌通过提高子质量来适应竞争压力,这是减少子数量的权衡.

关键词:

这种细菌是 Bacillus subtilis.沙门氏菌 Typhimurium 是一个类型.标志 SigB 标志 B 标志 B 标志在T6SSSS中使用.跨物种的相互作用.病原体是一种病原体.益生菌益生菌是一种益生菌.球体的分泌和分泌.

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