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Updated: May 10, 2026

Peptide-based Identification of Functional Motifs and their Binding Partners
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Published on: June 30, 2013

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一个细胞内图书馆选平台识别了不可逆转的共价转录因子抑制剂

Andrew Brennan1, Scott Lovell1, Keith W Vance1

  • 1Department of Life Sciences, University of Bath, Bath, BA2 7AY, UK.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
|March 18, 2025
PubMed
概括

研究人员开发了一个新的选平台,以找到转录因子 (TF) 的共价抑制剂. 这种方法确定了一种强效的,可不可逆地阻断致癌性TFcJun,抑制癌细胞活力.

关键词:
激活剂蛋白-1-1 的作用.cJun 的意思是什么作为一种共价抑制剂.抗剂的抗剂.蛋白质蛋白质相互作用转录因子的转录因子

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Eukaryotic Transcription Inhibitors01:52

Eukaryotic Transcription Inhibitors

Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
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