饮食中的多醇对血管性勃起功能障碍的影响:临床前研究的系统审查
Rafaela Geraldo1,2, Catarina Castro1, Elisabete Pinto1
1CBQF, Centro de Biotecnologia e Química Fina, Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Porto, Portugal.
Phytotherapy research : PTR
|March 18, 2025
概括
饮食中的多,如EGCG,氨酸,白醇和黄素,通过减少炎症和氧化应激,有望改善勃起功能 (ED). 需要进一步的临床试验来确认它们的有效性和最佳使用在管理ED.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 勃起功能障碍 (ED) 构成了重大的健康挑战,目前的治疗方法,如PDE5抑制剂在严重病例,特别是糖尿病病例中有效性有限.
- 饮食中的类化合物具有抗氧化和抗炎性质,表明其可能是ED的补充干预措施.
研究的目的:
- 系统地审查特定的饮食多醇epigallocatechin gallate (EGCG),奎尔塞丁,白醇和黄对勃起功能障碍的病理生理学的影响.
主要方法:
- 根据PRISMA 2020指南进行了系统审查,搜索了PubMed,Scopus和Web of Science,直到2024年10月.
- 收录标准集中在原始的英语文章上,不包括in silico,评论和编辑研究,以及缺乏多醇的细节.
- 使用GRADE和SYRCLE ROB工具进行了包括的26项研究 (动物,ex vivo,体外) 的质量评估,表明质量中等至高.
主要成果:
- 经过审查的多醇始终表现出对行为,功能,分子和荷尔蒙参数的勃起功能产生积极影响.
- 这些化合物在与ED病理生理学相关的机制中表现出改善,这可能是由于它们的抗氧化和抗炎作用.
结论:
- 饮食中的多醇显示出作为勃起功能障碍的辅助疗法的潜力,在临床前和体外研究中得到一致的发现支持.
- 显著的局限性包括依赖动物模型和人类临床试验的必要性,以确定在ED管理中临床应用的疗效,最佳剂量和安全性.
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