酒精和吸烟习惯与肝细胞癌风险相关
Elom K Aglago1, Ines Ramos1, Pekka Keski-Rahkonen1
1Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.
International journal of cancer
|March 18, 2025
概括
吸烟和饮酒是肝细胞癌 (HCC) 的重要独立风险因素. 这项研究没有发现证据表明这些习惯在协同作用下增加HCC风险,尽管需要进一步研究.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 癌症流行病学 癌症流行病学
- 代谢学 代谢学 代谢学
背景情况:
- 肝细胞癌 (HCC) 是一个主要的全球健康问题.
- 吸烟和饮酒已成为HCC的风险因素.
- 了解这些风险因素之间的相互作用对于预防策略至关重要.
研究的目的:
- 调查吸烟和饮酒对HCC风险的独立和相互作用影响.
- 用吸烟和饮酒的客观血清生物标志物验证调查问卷数据.
- 评估吸烟和酒精在HCC发展中的潜在协同作用.
主要方法:
- 利用了来自欧洲前性癌症调查 (EPIC) 队列的450,112名参与者的数据.
- 在队列中采用了一个嵌套的病例控制研究,包括108例高血压瘤病例和108个匹配的对照.
- 分析了吸烟 (cotinine,尼古丁) 和酒精 (2-hydroxy-3-methylbutyric acid) 的生物标志物,使用非向的代谢学.
主要成果:
- 当前吸烟者表现出HCC风险的剂量依赖性增加 (HR=2.46).
- 与轻度饮酒者相比,前,定期重度饮酒者和始终重度饮酒者显示HCC风险较高.
- 生物标记分析证实,高水平的丁,尼古丁和2-基-3-甲基黄油酸增加了HCC风险.
- 没有观察到吸烟和饮酒之间对HCC风险的统计学上显著的乘法或添加相互作用.
结论:
- 吸烟和饮酒被证实是HCC的强大,独立的风险因素.
- 该研究没有发现吸烟和酒精之间在增加HCC风险方面的协同相互作用的证据.
- 建议进行更大的队列研究,以进一步阐明潜在的复杂相互作用.
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