1型糖尿病成年人吸入技术层胰岛素加上胰岛素降解剂:INHALE-3扩展研究
Roy W Beck1, Ryan J Bailey1, Klara R Klein2
1JAEB Center for Health Research, Tampa, Florida, USA.
Diabetes technology & therapeutics
|March 18, 2025
概括
吸入的技术界胰岛素 (TI) 与 degludec 结合,在 30 周内在 1 型糖尿病 (T1D) 中持续控制 HbA1c. 这种TI方案为自动注射胰岛素 (AID) 和多次每日注射 (MDI) 提供了可行的替代方案.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- 饭后高血糖是1型糖尿病 (T1D) 管理的一个挑战,即使有自动胰岛素输送 (AID).
- 皮下注射的快速作用胰岛素类似物具有延迟的发作,导致饭后葡萄糖升.
- 吸入的技术界胰岛素 (TI) 提供更快的起作用,可能改善饭后血糖控制.
研究的目的:
- 为了评估30周治疗方案的疗效和可持续性,在T1D的成年人中将吸入的技术圈胰岛素 (TI) 与胰岛素降水剂结合起来.
- 为了比较TI-degludec疗法与常规护理,主要是自动胰岛素输送 (AID) 或多次每日胰岛素注射 (MDI).
主要方法:
- 一项为期17周的多中心随机对照试验,涉及123名T1D成年人.
- 与常规护理 (AID或MDI) 相比,TI加胰岛素降解剂治疗方案的比较.
- 延长阶段允许TI-degludec组的参与者继续治疗13周,接近现实世界的坚持.
主要成果:
- 在TI-degludec疗法下,HbA1c水平在30周内维持 (起始值:7.6%,17周:7.6%,30周:7.4%).
- 从第17周到第30周观察到HbA1c显著下降 (-0.21%,P < 0.001).
- 达到HbA1c<7.0%的参与者比例从基线时的21%增加到30周后的42%.
结论:
- 一种结合吸入技术圈胰岛素 (TI) 与胰岛素降水的治疗方案表明,在1型糖尿病患者中,持续的血糖控制.
- 这种TI-degludec疗法为T1D患者提供了有价值的治疗选择,可能为AID和MDI提供了替代方案.
- 应考虑TI作为1型糖尿病管理人员的治疗选择.
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