标准化Rhodiola rosea注射用于左心室重塑和炎症在HFrEF患者:一个系统的审查和元分析
Xuqin Du1, Xiaorong Wang2, Ruodai Zhang2
1School of Traditional Chinese Medicine, Chongqing University of Chinese Medicine, Chongqing, China.
Frontiers in pharmacology
|March 18, 2025
概括
标准化Rhodiola rosea注射 (SRRI) 改善左心室重塑,并减少心力衰竭患者的炎症减少喷射率 (HFrEF) 患者. 这种植物性治疗显示出增强的临床有效性,具有有利的安全性.
科学领域:
- 心脏病学 心脏病学
- 药理学 药理学是指药理学的学科.
- 综合医学是一个整体的医学.
背景情况:
- 减少喷射分数 (HFrEF) 的心力衰竭是一个重大的全球健康问题.
- 左心室重塑 (LVR) 和炎症是HFrEF进展的关键驱动因素.
- 标准化罗迪奥拉 (Rhodiola rosea) 注射剂 (SRRI),是一种植物制剂,在中国用于心力衰竭,并具有已知的抗氧化和抗炎性质.
研究的目的:
- 系统地评估SRRI对诊断为HFrEF的患者左心室重塑 (LVR) 和炎症介质的影响.
主要方法:
- 随机对照试验 (RCT) 的系统审查和元分析是按照PRISMA和Cochrane指南进行的.
- 在八个数据库中搜索到2024年10月HFrEF治疗中SRRI的RCT.
- 使用Cochrane偏差风险和修改的Jadad尺度评估研究质量;使用Stata 17.0分析数据,包括敏感性和出版偏差分析.
主要成果:
- 涉及2325名参与者的25个RCT表明SRRI显著改善了LVR (增加LVEF,减少LVEDD和LVESD).
- SRRI显著降低了关键的炎症媒介 (TNF-α,IL-6,hs-CRP) 和心脏生物标志物 (BNP,NT-pro BNP).
- 临床有效性得到增强,但并没有显著增加不良事件,并且在敏感性分析中发现的结果是强大的.
结论:
- SRRI在改善LVR,减少炎症和改善HFrEF患者的临床结果方面表现出有效性,具有良好的安全性.
- 目前的证据虽然有希望,但受限于方法上的缺陷.
- 建议进一步进行高质量的多中心RCT,以在不同人群和长期持续时间中验证这些发现.
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