没有怀疑的T4非小细胞肺癌用额外的肺内结节治疗
Arvind Kumar1, Deepti Srinivasan2, Gabe Smock2
1Department of Thoracic Surgery, Icahn School of Medicine at Mount Sinai, New York, New York.
Annals of thoracic surgery short reports
|March 18, 2025
概括
对于非小细胞肺癌 (NSCLC) 具有未被怀疑的结节,仅切除主要瘤的手术显示出与延长切除相似的存活率. 仔细选择患者和辅助疗法是最佳结果的关键.
科学领域:
- 胸部外科手术 胸部外科手术
- 手术瘤学手术瘤学
- 肺部病理学 肺部病理学
背景情况:
- 在手术期间,非小细胞肺癌 (NSCLC) 的最佳治疗方法与未被怀疑的肺内结节 (pT4-Add) 仍然不清楚.
- 这项研究调查了对初级瘤切除与包括额外结节在内的扩展切除进行比较的结果.
研究的目的:
- 为了比较未被怀疑的pT4-添加NSCLC患者的整体存活率和短期结果.
- 评估一次性切除与延长切除对患者存活率的影响.
主要方法:
- 对339名患有cT1-3 N0-1 M0 NSCLC和未被怀疑的pt4-Add疾病的患者进行了回顾性分析 (国家癌症数据库,2010-2015年).
- 使用Kaplan-Meier分析和10个变量上的倾向性得分匹配的初级切除部位和扩展切除组之间的比较.
主要成果:
- 主要切除部位 (83名匹配患者) 和延长切除部位 (42名匹配患者) 之间在5年总生存期没有显著差异.
- 72.3%的患者接受了初级切除,而27.7%的患者接受了扩展切除.
结论:
- 对于经过精心挑选的患有未被怀疑的pT4-Add NSCLC的患者,初级切除部位可能会提供与延长切除相似的整体存活率.
- 适当的辅助治疗对于在这种情况下接受初级切除部位的患者至关重要.
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