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Updated: May 21, 2025

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由于心脏 Amyloidosis 的原因而导致的急性 mitra 乳头肌肉破裂

Takashi Nagase1, Noriyuki Kashiyama1, Natsumi Horikawa1

  • 1Department of Cardiovascular Surgery, Fukui Cardiovascular Center, Fukui, Japan.

Annals of thoracic surgery short reports
|March 18, 2025
PubMed
概括

心脏粉症可能导致罕见的乳头肌肉破裂,导致急性额头肌反和休克. 这一案例凸显了在患有不明原因的乳头肌肉破裂的患者中考虑心脏粉症的必要性.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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