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在胃癌中重新编程与瘤相关的巨细胞:通往增强免疫治疗的途径

Yibo He¹, Qianran Hong¹, Shiliang Chen¹

¹The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, Zhejiang, China.

Frontiers in immunology

|March 18, 2025

概括

针对胃癌 (GC) 中的瘤相关巨细胞 (TAM) 显示出改善患者结果的希望. 战略重点是将免疫抑制M2 TAM重编程为抗瘤M1表型,增强癌症疗法.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
癌症生物学癌症生物学

背景情况:

胃癌 (GC) 是一个重大的全球健康挑战,预后不佳,治疗选择有限,特别是在晚期.
瘤微环境 (TME),特别是与瘤相关的巨细胞 (TAMs),极大地影响瘤的进展,免疫逃避和对治疗的抗性.
TAMs是塑料的,M2表型在GC中占主导地位,与不良结果相关.

研究的目的:

审查针对胃癌中TAMs的近期治疗进展.
探索包括纳米技术,代谢重编程和TAM调节途径抑制在内的新策略.
突出TAM向胃癌治疗的挑战和未来方向.

主要方法:

对胃癌中TAMs的当前文献的综述.
对针对TAM两极化和功能的新兴治疗策略的分析.
讨论与TAM异质性和选择性准相关的挑战.

主要成果:

TAMs,特别是M2表型,促进胃癌的进展和免疫抑制.
治疗策略包括抑制M2极化,M1重编程以及与免疫检查点抑制剂的联合治疗.
纳米技术,代谢重编程以及像IL-6和CCL2/CCR2这样的向途径提供了创新的方法.

结论:

向TAMs代表了胃癌的一个有希望的治疗途径.
克服TAM异质性和确保选择性向是有效治疗的关键挑战.
在TME中对TAM生物学进行进一步的研究对于开发精确有效的胃癌疗法至关重要.

关键词:

胃癌胃癌是一种胃癌.免疫疗法免疫疗法巨细胞的两极分化瘤微环境是一个微环境.与瘤相关的巨细胞.

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