在乳腺癌早期阶段内分泌治疗的升级和降级策略
Tamer Al-Batsh1, Nayef Abdel-Razeq2, Yosra Al-Masri1
1Section of Hematology and Medical Oncology, Department of Internal Medicine, King Hussein Cancer Center, Amman, 11941, Jordan.
Biologics : targets & therapy
|March 18, 2025
概括
辅助内分泌疗法 (ET) 改善了激素受体阳性早期乳腺癌 (EBC) 的结果. 较新的向疗法和降级策略提供个性化治疗,以减少复发和改善生存率.
科学领域:
- 在瘤学瘤学.
- 乳腺癌研究研究 乳腺癌研究
- 药理学 药理学是指药理学的学科.
背景情况:
- 辅助内分泌疗法 (ET) 是激素受体阳性早期乳腺癌 (EBC) 的标准,但超过20%的患者复发.
- 复发往往呈现为无法治愈的远程转移,强调了需要改进辅助策略的需要.
- 使用性腺激素释放激素激动剂 (GnRHa) 与ET结合的卵巢功能抑制 (OFS) 已显示出生存益处.
研究的目的:
- 审查HR阳性EBC的辅助疗法的进展.
- 探索新的目标代理和降级策略的作用.
- 强调个性化辅助治疗方法的趋势.
主要方法:
- 对HR阳性EBC的辅助疗法进行的临床试验和研究的审查.
- 对CDK4/6抑制剂,PARP抑制剂和EBC中的OFS数据的分析.
- 在治疗决策中评估降级策略和基因组分析.
主要成果:
- CDK4/6抑制剂 (abemaciclib, ribociclib) 在高风险的EBC中显示出有前途.
- PARP抑制剂olaparib显著改善了BRCA突变EBC的无侵袭性疾病生存率和整体生存率.
- 缓和策略,如暂时的妊娠中断,正在为低风险患者出现.
结论:
- 个性化辅助疗法正在发展,集成向治疗 (CDK4/6抑制剂,PARP抑制剂) 和优化ET与OFS.
- 通过降级策略,平衡有效性与生活质量至关重要.
- 量身定制的方法旨在改善HR阳性EBC患者的长期结果.
相关概念视频
Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
Mitogens and the Cell Cycle
6.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.4K
Target Cell Response to Hormones
2.8K
Hormones intricately bind to receptors on the surface or within target cells, initiating a cascade of cellular responses.
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
Notably, the cellular response can be regulated by altering the number of receptors expressed in the cell. For example, prolonged exposure to elevated hormone levels results in a gradual decline or down-regulation in the number of receptors for that specific hormone on the cell surface. Conversely, in response to low hormone levels, cells may use up-regulation, producing an...
2.8K
Tumor Immunotherapy
454
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
454


