在上呼吸道疾病中通过脉冲雾化器进行布德索尼德雾化的增强治疗选择
Bolesław Samoliński1, Konrad Furmańczyk2, Andrzej Emeryk3
1Department of Public and Environmental Health, Division of Environmental Hazard Prevention, Allergology, and Immunology, Medical University of Warsaw, Poland.
Otolaryngologia polska = The Polish otolaryngology
|March 18, 2025
概括
这项研究表明,测试和参考布德索尼德配方都有效治疗使用脉冲雾化器治疗具有鼻息肉的慢性鼻炎. 振动气溶输送系统增强药物透,改善治疗结果.
科学领域:
- 药理学 药理学是指药理学的学科.
- 呼吸系统医学 呼吸系统医学
- 药物输送系统 药物输送系统
背景情况:
- 局部用葡萄糖皮质类固醇是T2免疫反应相关的呼吸道炎症的首要治疗方法,如eosinophilic炎症.
- 药物透到周鼻腔限制了局部葡萄皮质类固醇的有效性.
- 脉冲性雾化器可以提高药物的透到鼻,为慢性鼻炎提供新的治疗选择.
研究的目的:
- 为了比较测试药物 (TD) 和参考药物 (RD) 的气动粒子大小分布 (APSD) 的布德索尼德悬浮液.
- 为了评估通过脉动雾化器系统输送的布德索尼德的疗效,用于患有鼻息肉的慢性鼻炎.
主要方法:
- 使用PARI SINUS2雾化器系统进行TD和RD的APSD比较.
- 使用下一代冲击器 (NGI) 和激光衍射光谱仪进行APSD分析.
- 进行统计分析,包括平均值和比率的置信区间.
主要成果:
- 两种TD和RD配方都显示了气溶滴分布的变化.
- TD产生了更大的水滴,促进了冲击器上层的沉积.
- 在慢性鼻炎中通过脉冲雾化器治疗鼻息肉时,RD和TD布埃索尼德的等价性已被证明.
结论:
- 在这项研究中,budesonide的两种配方都被证明是有效的.
- 通过振动雾化输送的布德索尼德是一种有效的治疗慢性鼻炎与鼻.
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