基于不良结果途径的海上酸盐和微塑料的繁殖作用
Xukai Lan1, Xiaopeng Pang1, Karsoon Tan2
1International Research Center for Marine Biosciences at Shanghai Ocean University, Ministry of Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Environmental science & technology
|March 18, 2025
概括
微塑料和DEHP通过作为抗雌激素来破坏的繁殖,从而损害卵巢的发育和功能. 这项研究引入了一种新的不良结果途径 (AOP),以了解海洋生物中的微塑料毒性.
科学领域:
- 环境毒理学环境毒理学
- 海洋生物学 海洋生物学
- 内分泌学 在内分泌学.
背景情况:
- 微塑料污染是一个全球性的问题,由于它们的过性质,海非常容易受到污染.
- 甲酸 (PAE) 甲酸 (DEHP) 等甲酸 (PAE) 可以从微塑料中浸出并作为内分泌干扰剂.
- DEHP是一种常见的塑化剂和已知的内分泌干扰剂,引发了对其对海洋生物的影响的担忧.
研究的目的:
- 研究微塑料和DEHP对雌性贝Mytilus coruscus的生殖功能的影响.
- 阐明DEHP和微塑料暴露引起的生殖功能障碍背后的分子机制.
- 引入一种新的不良结果途径 (AOP) 框架,用于评估贝类中的微塑料诱导的生殖毒性.
主要方法:
- 暴露于DEHP和高密度聚乙烯 (HDPE) 微塑料中的.
- 分子变化的分析,包括雌激素受体 (ER) 结合和ER,CYP3和17β-HSD的基因表达.
- 在卵巢组织中测量雌激醇和孕水平.
- 卵巢组织中抗氧化能力的评估.
主要成果:
- 暴露于DEHP与HDPE一起,通过与ER结合,抑制ER,CYP3和17β-HSD基因表达,启动了抗雌激素效应.
- 在暴露的贝的卵巢组织中观察到雌激素和孕的水平降低.
- 卵巢组织中抗氧化能力受损导致卵巢发育受阻,生殖功能受损.
- 建立了一个新的AOP,详细说明从分子启动事件到贝繁殖不良结果的序列.
结论:
- 通过抗雌激素机制,DEHP和微塑料协同作用,破坏的生殖功能.
- 已确定的AOP为了解和评估微塑料相关化学品对海洋贝类的风险提供了一个框架.
- 这项研究强调了微塑料和相关的塑化剂对海洋生态系统和生物多样性的重大威胁.
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