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Updated: May 21, 2025

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自杀性Arg/N-degron通路ATE1 R-转移酶的结构功能关系

Su Bin Kim1, Ji Su Lee1, Xin Lan2

  • 1Cellular Degradation Biology Center, and Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul, Korea.

Autophagy
|March 18, 2025
PubMed
概括

甲基转移酶1 (ATE1) 选择性地将氨酸添加到蛋白质中,从而产生N-降解子,这些N-降解子通过ubiquitin-proteasome系统 (UPS) 或自-lysosome系统 (ALS) 准它们进行降解. 结构分析揭示了ATE1的存在.

关键词:
在ATE1中,ATE1是ATE1.在N-degron中降解.没有认可.这是一种Nt-arginylation.在SQSTM1/p62/sequestosome1中,我们使用SQSTM1/p62/sequestosome1.酸转移酶是一种酸转移酶.

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