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Updated: May 21, 2025

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诺奇1和主要密室蛋白调节了质母细胞瘤中的泰莫佐洛米德抗性

Cengiz Tuncer1, Ceyhan Hacioglu2,3

  • 1Faculty of Medicine, Department of Neurosurgery, Düzce University, Düzce, Turkey.

Journal of cellular and molecular medicine
|March 18, 2025
PubMed
概括

在多形质母细胞瘤 (GBM) 中准Notch1可以克服temozolomide (TMZ) 耐药性. 抑制Notch1通过降低MVP,MGMT和ABCG2等抗性蛋白的调节来减少扩散,并使GBM细胞对TMZ重新敏感.

关键词:
质母细胞瘤多形一个主要的宝库蛋白质.有一个口,有个口.泰莫索洛米德 (temozolomide) 是一种有毒的物质.

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