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Updated: May 21, 2025

Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro
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Isolation of Mouse Interstitial Valve Cells to Study the Calcification of the Aortic Valve In Vitro

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尿酸通过介导间细胞骨质分化和内皮功能障碍促进大动脉结石化

Jialiang Zhang1,2,3, Wenhua Lei1,2,3, Jing Zhou1,2,3

  • 1Laboratory of Cardiac Structure and Function, Institute of Cardiovascular Diseases, West China Hospital, Sichuan University, Chengdu, P.R. China.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
|March 18, 2025
PubMed
概括

高尿酸水平有助于导致大动脉膜化. 降低尿酸或抑制缺氧诱导因子-1α (HIF-1α) 可能为这种情况提供新的治疗策略.

关键词:
这是一个HIF-α.大动脉膜化 化细胞内膜屏障的障碍物骨质性分化的骨质性差异化尿酸是什么 尿酸是什么 尿酸是什么

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In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
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