通过伊米达-氧化物修饰对石墨烯氧化物的调毒性概况:斑马鱼作为模型系统
Serkan Yıldırım1,2, Mine Köktürk3,4, Aybek Yiğit4,5
1Department of Pathology, Veterinary Faculty, Ataturk University, Erzurum, Turkiye.
Environmental toxicology and chemistry
|March 18, 2025
概括
石墨烯氧化物 (GO) 导致斑马鱼发育问题和DNA损伤. 然而,用氧化物 (GO-OX) 功能化的GO显著降低了这些有毒效应,表明了更安全的纳米材料用于应用.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 纳米技术纳米技术
背景情况:
- 纳米材料 (NM) 越来越多地用于农业和食品,引发健康和环境问题.
- 石墨烯氧化物 (GO) 是一个著名的NM,具有潜在的应用,但未知风险.
研究的目的:
- 研究合成的氧化石墨烯 (GO) 和其衍生物对斑马鱼的毒性影响.
- 评估神经毒性,DNA损伤和发育影响.
主要方法:
- 斑马鱼被暴露在GO,石墨烯氧化氧化物 (GO-OX) 和OX中96小时.
- 评估了形态变化,组织病理学,化,生存率和免疫光标记 (8-OHdG,NOP10).
主要成果:
- GO暴露减少了化/生存,诱导形,DNA损伤 (8-OHdG),并增加了NOP10表达.
- GO-OX和OX表现出剂量依赖的抑制作用,GO导致更严重的组织损伤.
- GO-OX治疗减轻了形态和神经毒性影响,表明毒性降低.
结论:
- 石墨烯氧化物在斑马鱼中表现出显著的神经毒性和发育效应.
- GO (GO-OX) 的氧化物功能化有效地减轻了其不良影响.
- GO-OX为纳米技术应用提供了一个潜在的更安全的替代方案.
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