1型糖尿病骨质疏松症的患病率和危险因素 - - 来自一项观察性研究的结果
Jakob Starup-Linde1, Julie Støy2,3, Pernille Bundgaard Grinderslev4,2
1Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, Aarhus N, 8200, Aarhus, Denmark. jakolind@rm.dk.
概括
有相当数量的1型糖尿病患者患有骨质疏松症. 建议对绝经后妇女和50岁以上患有T1D的男性进行骨质疏松症查,以减少骨折风险.
科学领域:
- 内分泌学 在内分泌学.
- 代谢性骨疾病 代谢性骨疾病
- 糖尿病是一种糖尿病.
背景情况:
- 1型糖尿病 (T1D) 与较高的骨折风险有关.
- 目前的骨质疏松症治疗门对于T1D患者来说可能过于严格.
- 对于骨质疏松症治疗,建议修订的T-score截止值为≤-2.0.
研究的目的:
- 使用世卫组织和拟议的ADA标准来确定T1D中骨质疏松症的患病率.
- 确定T1D患者骨质疏松症的危险因素.
- 评估修订后的治疗指南对T1D患者的影响.
主要方法:
- 一项涉及764名T1D患者的横截面研究,对骨质疏松症进行了查.
- 对腰椎和部进行了双能X射线吸收计 (DXA).
- 从2020年至2022年期间从T1D诊所收集的数据.
主要成果:
- 根据世卫组织的标准,25.5%的T1D患者患有骨质疏松症 (T-score ≤-2.5或脊椎骨折).
- 36%的人符合拟议的ADA治疗标准 (T-score ≤ -2.0或脊椎骨折).
- 增加的年龄和家族骨质疏松病史是危险因素;更高的BMI是保护性的.
结论:
- 很大一部分T1D患者患有骨质疏松症或符合修订后的治疗标准.
- 在T1D中早期检测和治疗骨质疏松症可以减轻骨折风险.
- 建议对绝经后的女性和50岁以上的T1D男性进行查.
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