缓解循环胺诱导的肝毒性:林纳在调节氧化应激,炎症和亡中的作用
Gharam Saad Alserhani1,2, Maged E Mohamed1, Nancy Safwat Younis3
1Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, 31982, Al-Ahsa, Saudi Arabia.
Naunyn-Schmiedeberg's archives of pharmacology
|March 18, 2025
概括
利纳 (LIN) 通过减少氧化应激,炎症和亡来保护抗循环胺 (CP) 诱导的肝脏和脏损伤. 这项研究突出了LIN LIN的重点.
科学领域:
- 药理学 药理学是指药理学的学科.
- 毒理学 毒理学 毒理学
- 自然产品化学 自然产品化学
背景情况:
- 环胺 (CP) 是一种广泛使用的化疗剂,已知会引起严重的肝脏和脏毒性.
- 林醇 (LIN) 是一种在精油中发现的天然非循环单醇,已表现出各种生物活性.
- 需要确定防护剂,防止CP引起的器官损伤.
研究的目的:
- 在大鼠模型中研究林纳 (LIN) 对循环胺 (CP) 诱导的肝脏和脏毒性的保护作用.
- 阐明潜在的机制,包括氧化应激,炎症和亡途径.
主要方法:
- 鼠被用Linalool (50或100毫克/公斤) 口服治疗了14天,随后是单剂量环胺 (200毫克/公斤,ip).
- 评估了肝脏和功能测试,组织病理学检查,氧化应激标志物,炎症调解物和亡标志物.
- 进行了JAK2/STAT3/NFκB通路的基因表达和LIN与JAK2的分子对接.
主要成果:
- 林醇的使用显著降低了肝酶 (ALT,AST,γGTT1) 和功能标志物 (BUN,肌素,尿酸).
- 林治疗增加了抗氧化能力 (GST,GSH-Px,SOD,catalase) 和降低了氧化应激标志物 (MDA,NO).
- 通过降低JAK2/STAT3/NFκB的调节,LIN显著减弱了炎症标志物 (TNF-α,IL-6,IL-1β) 和亡标志物 (Bax,caspase-3,caspase-9).
结论:
- 利纳在老鼠中表现出显著的肝保护和保护作用,防止循环胺诱导的毒性.
- 保护机制包括减轻氧化应激,炎症和亡,可能通过JAK2 / STAT3 / NFκB途径.
- 林纳醇代表了一种有前途的天然化合物,用于预防或治疗与环胺相关的器官损伤.
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