夜间缩血压降低率和周周结膜白质过强度与帕金森病的认知功能有关
Lanlan Chen1, Tingting Qiao1, Cancan Ma1
1Department of Neurology, Clinical Medical College, Northern Jiangsu People's Hospital, Yangzhou University, No. 98 West Nantong Road, Yangzhou, 225001, China.
概括
减少夜间缩血压降低与帕金森病患者的认知能力下降有关. 这可能导致白质过强度和认知障碍.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 老年学是一门学科.
背景情况:
- 帕金森病 (PD) 与认知障碍有关.
- 白质过强度 (WMH) 在PD中很常见,可能会影响认知.
- 血压调节,特别是夜间缩血压 (NSBP),与神经疾病有关.
研究的目的:
- 研究在PD患者中NSBP降低率,WMH和认知功能之间的关系.
- 确定与帕金森病认知衰退相关的因素.
主要方法:
- 在PD参与者身上进行了24小时的门诊血压监测和MRI.
- 量化了WMH体积,参与者被分为正常和非浸泡血压组,痴呆症和非痴呆症组.
- 使用多变量线性回归分析来确定认知功能的独立风险因素.
主要成果:
- 与正常水者相比,非水者表现出明显较低的认知分数 (MoCA) 和较高的WMH体积.
- 痴呆症组的各种WMH类型与白质 (WM) 的比率明显高于非痴呆症组.
- 较低的NSBP降低率和较高的周周结膜WMH与WM比率是PD认知障碍的独立风险因素.
结论:
- 减少NSBP的速率和周周结膜WMH与WM的比率与PD患者的认知功能有关.
- 减少NSBP减少可能在WMH的发展和随后的PD认知障碍中发挥作用.
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