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Updated: May 21, 2025

Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism
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Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism

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使用随机定位常数-pH元动力学模拟来表征RNA寡合体.

Tomás F D Silva1, Giovanni Bussi1

  • 1Scuola Internazionale Superiore di Studi Avanzati, Trieste 34136, Italy.

Journal of chemical information and modeling
|March 18, 2025
PubMed
概括

这项研究验证了一种用于研究RNA灵活性和pH依赖性质的新计算方法. 增强的恒定pH分子动力学 (CpHMD) 准确预测RNA pKa值,为生物功能提供了洞察力.

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RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
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