胃食道逆流疾病和耳鼻喉疾病之间的关联
Yixi Xiao1,2, Haowei Zhang3, Fang Zhang2
1Department of Otolaryngology Head and Neck Surgery, The Affiliated Hospital of North Sichuan Medical College, Nanchong, China.
Medicine
|March 18, 2025
概括
胃食道逆流性疾病 (GERD) 与几种耳鼻喉疾病的风险增加有关,包括鼻炎和睡眠呼吸暂停. 这项门德尔随机化研究表明,GERD可能在这些头疾病中起因作用.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 胃肠病学 胃肠病学
- 遗传学 遗传学 是一个
- 流行病学 流行病学
背景情况:
- 胃食道逆流性疾病 (GERD) 是一种常见的疾病,具有潜在的全身影响.
- GERD和耳鼻喉疾病之间的关系需要使用可靠的方法进一步调查.
研究的目的:
- 通过使用双样本的门德尔随机化 (MR) 分析,调查GERD和16种常见的耳鼻喉疾病之间的潜在因果关系.
- 评估GERD在各种耳鼻喉疾病发展中的遗传倾向.
主要方法:
- 使用了双样本的门德尔随机化 (MR) 设计,使用与GERD密切相关的单核酸多态 (SNP) 作为仪器变量.
- 应用逆方差权衡 (IVW) 作为主要分析方法,使用MR Egger,加权中位数和其他敏感性分析方法.
- 进行了异质性,质性和抛出分析,以确保研究结果的稳定性和有效性.
主要成果:
- 基因预测的GERD与急性上呼吸道感染,慢性喉炎,声带功能障碍,睡眠呼吸暂停,急性鼻炎,慢性鼻炎和慢性性耳中炎的风险增加显著相关.
- 几率比 (ORs) 从急性上呼吸道感染的1.14到声带功能障碍的2.30不等,所有P值<0.003.
- 灵敏度分析表明没有显著的证据,支持因果推断的pleiotropy.
结论:
- 这些发现表明,GERD与几种耳鼻喉疾病的风险增加之间存在潜在的因果关系.
- GERD可能是导致诸如鼻炎,睡眠呼吸暂停和慢性喉炎等疾病发展的因素.
- 需要进一步的研究来阐明潜在的生物机制,并探索针对耳鼻喉疾病的潜在治疗策略.
相关概念视频
Gastroesophageal Reflux Disease II: Clinical Features and Management
42
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
42
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology
261
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
261
Esophageal Strictures-I: Introduction
47
Esophageal strictures involve abnormal narrowing or tightening of the esophagus. They vary in length and severity, ranging from mild constriction to complete obstruction, and are classified as benign (noncancerous) or malignant (cancerous).
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
Etiology
The primary cause of esophageal strictures is long-standing gastroesophageal reflux disease (GERD), accounting for about 70 to 80% of adult cases. Chronic acid reflux can lead to injury and scarring of the esophageal lining, culminating in...
47
Other Disorders of Digestive System
641
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
641
Barrett Esophagus-II: Clinical Manifestations and Management
91
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
91
Barrett Esophagus-I: Introduction
50
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
50


