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Updated: May 5, 2026

Solid-phase Synthesis of [4.4] Spirocyclic Oximes
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一个意想不到的 [3 + 2] 循环添加 间的 螺旋-环氧氧化和 γ-解布丁化物 催化由 Sc ((OTf)3

Jing-Liang Yu1,2, Qian-Mao Zhang1,2, Guo Cheng1,2

  • 1Key Laboratory of Asymmetric Synthesis and Chirotechnology of Sichuan Province, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China.

The Journal of organic chemistry
|March 18, 2025
PubMed
概括

研究人员开发了一种新的催化循环添加反应. 这种方法在温和的条件下有效地创建复杂的螺旋-oxindole结构与多个立体中心.

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Epoxidation of alkenes via oxidation with peroxy acids involves the conversion of a carbon–carbon double bond to an epoxide using the oxidizing agent meta-chloroperoxybenzoic acid, commonly known as MCPBA. Since the O–O bond of peroxy acids is very weak, the addition of electrophilic oxygen of peroxy...
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