放射性污染物通过皮肤透:目前的理解
Fernandes C S A1,2, Sureshkumar M K1
1Health Physics Division, Bhabha Atomic Research Centre, Mumbai 400085, India.
概括
放射性化学物质通常显示皮肤吸收率较低,完整的皮肤阻断了大多数. 损坏的皮肤和特定的化合物,如-125显著增加放射化学透,突出地突出了角层.
科学领域:
- 辐射保护 辐射保护
- 皮肤病学 皮肤病学
- 毒理学 毒理学 毒理学
背景情况:
- 了解通过皮肤的放射化学透对于评估污染风险至关重要.
- 之前的研究已经研究了各种放射性核素和皮肤疾病,产生了不同的结果.
研究的目的:
- 通过完整和受损皮肤进行放射化学透的现有知识进行审查和综合.
- 确定影响放射性核素皮肤吸收的因素,并比较不同的实验模型.
主要方法:
- 审查涉及人类志愿者,动物模型和意外污染的研究.
- 对各种放射性化学物质 (如,美洲,,技术,) 的透数据的分析.
- 在体内和体外方法以及不同皮肤模型的比较.
主要成果:
- 完整的皮肤显示了大多数研究的放射化学物质的低分量吸收 (<0.1%至<1%).
- 化学损伤的皮肤和化剂 (如DTPA) 显著增加透率 (1-10%).
- -125和技术-99m甲酸通过完整的猪皮具有很高的透率 (高达60%);的结果是不确定的.
- 角层是主要的屏障;它的损伤大大提高了透.
结论:
- 皮肤的透性因放射性化学物质的特性和皮肤的完整性而异.
- 动物皮肤模型可能高估了人类皮肤的透性.
- 需要进一步的研究来阐明放射性化学皮肤传输的机制.
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