皮质体感官引起的响应对外围神经刺激的频率依赖与受控的 afferent 刺激
Disha Gupta1,2, Jodi Brangaccio1, Helia Mojtabavi1
1US. Department of Veterans Affairs, National Center for Adaptive Neurotechnologies, Stratton VA Medical Center, Albany, NY, United States of America.
Journal of neural engineering
|March 18, 2025
概括
H-反射向神经可塑性 (HrTNP) 协议可以改善运动功能. 这项研究测量了HRTNP期间的体感唤起潜力 (SEPs),发现N70的振幅随着频率的提高而下降,这表明了门效应.
科学领域:
- 神经科学是一个神经科学.
- 康复医学 康复医学 康复医学
- 生物医学工程 生物医学工程
背景情况:
- H-反射向神经可塑性 (HrTNP) 是一个有前途的康复策略,用于脑或脊髓损伤后的运动缺陷.
- 在HRTNP期间测量皮层反应,如体感唤起潜能 (SEP),可以阐明脊柱上机制.
- 标准的SEP协议与HRTNP刺激参数 (脉冲宽度,强度,频率) 有显著差异.
研究的目的:
- 调查在HRTNP刺激参数约束范围内SEP测量的可行性和特征.
- 具体分析刺激频率对HRTNP期间SEP组件 (P40,N70) 的影响.
- 为将SEP评估纳入HRTNP研究提供建议.
主要方法:
- 在13名受试者中,使用非侵入性脑电图记录了体感唤起潜能 (SEP).
- 在0.2,1和2Hz时进行神经刺激,通过唤起潜在操作者调节系统控制 afferent volley.
- 分析了P40和N70 SEP组件的幅度和延迟.
主要成果:
- 在测试频率 (0.2,1,2 Hz) 中,P40振幅和延迟保持不变.
- 随着频率的增加,N70的振幅显著下降 (39%在1Hz,57%在2Hz),表明神经门.
- N70振幅与刺激强度和M波振幅有显著的正相关性.
结论:
- 在HRTNP刺激约束范围内,SEP测量是可行的,为神经可塑性提供了洞察力.
- 刺激频率显著影响N70振幅,可能是由于封闭机制,需要在HRTNP协议中仔细考虑.
- 这些发现支持将SEP监测集成到HRTNP中,以了解脊柱上对运动恢复的贡献.
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