口服HPV发病率和获得HPV的风险因素
Gypsyamber DSouza1, Sakshi Tewari1, Tanya Troy1
1Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, USA.
Oral oncology
|March 18, 2025
概括
口腔HPV感染在艾滋病毒感染者和已有感染者中更为常见. 重复检测表明持续感染,突出显示HPV相关癌症的风险.
科学领域:
- 流行病学 流行病学
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 口服人类乳头瘤病毒 (HPV) 感染之前与HPV相关的口腔关癌症.
- 评估口腔HPV发病率对于了解癌症发展至关重要.
研究的目的:
- 评估艾滋病毒感染和没有艾滋病毒的人口HPV感染的发生率.
- 识别与口服HPV感染和持续性相关的风险因素.
主要方法:
- 未来的多中心队列研究.
- 每6-12个月收集口腔冲洗和 gargle 的样本.
- 对35种HPV类型进行了测试,其中包括13种瘤性类型 (oncHPV).
主要成果:
- 在1587名参与者中,有422名参与者在3.67年的中位随访期间检测到发生的口腔HPV.
- 最常见的瘤性HPV是HPV16 (发生率为7.8每1000人年).
- 在5年内,任何HPV,oncHPV和HPV16的累积发病率分别为34.9%,17.1%和4.0%.
结论:
- 口服HPV发病率在感染艾滋病毒 (PLWH) 的人和口服HPV流行的人群中较高.
- 口腔HPV感染包括新的和间歇性检测的感染.
- 重复检测口腔HPV与更高的累积发病率有关.
相关概念视频
Cancer Prevention
6.1K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.1K
Mechanisms of Retrovirus-induced Cancers
5.1K
Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.1K
Rous Sarcoma Virus (RSV) and Cancer
5.0K
Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
RSV is a retrovirus that contains two copies of a plus-strand RNA genome. Its genome consists of four main open...
5.0K
Sexually Transmitted Infections
286
Sexually transmitted infections (STIs) are diseases transmitted primarily through unsafe sexual interactions. Bacteria, viruses, or parasites cause them and can result in severe health complications if untreated.ChlamydiaThe bacterium Chlamydia trachomatis is responsible for the disease Chlamydia, the most common STI in the United States. This peculiar pathogen requires human cells to reproduce, residing intracellularly. The initial infection often goes unnoticed because it typically does not...
286
Factors Affecting the Risk of Infection
11.5K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.5K
Skin Cancer
4.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.0K


