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肠道微生物群通过损害子宫受体能力,参与聚乙烯微塑料诱导的缺陷植入
Jiani Sun1, Lulu Geng1, Dan Zhou1
1Centre for Assisted Reproduction, Shanghai Key Laboratory of Maternal-Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Journal of environmental management
|March 18, 2025
概括
暴露于小鼠中的微塑料会通过改变肠道微生物群并诱导铁亡,损害子宫的受容性和植入. 这项研究强调了肠道细菌在微塑料诱导的生殖毒性中的关键作用.
科学领域:
- 环境健康 环境健康
- 生殖生物学 生殖生物学
- 微生物组研究 微生物组研究
背景情况:
- 微塑料 (MP) 是无处不在的环境污染物,具有潜在的人类健康风险.
- 微塑料暴露对女性生殖健康的影响尚不清楚.
- 肠道微生物群的改变越来越多地与各种健康结果有关.
研究的目的:
- 在小鼠模型中研究口服聚烯微塑料 (PS-MP) 暴露对女性生殖健康的影响.
- 探索肠道微生物群变化在调解这些影响中的作用.
- 为了确定铁死是否与微塑料诱导的生殖功能障碍有关.
主要方法:
- 将PS-MPs口服给小鼠,以创建一个暴露模型.
- 评估子宫的受体性和植入成功.
- 使用元基因组测序分析便样本,以分析肠道微生物群.
- 检测铁灭菌标记物 (MDA,与铁灭菌有关的蛋白质).
主要成果:
- 在小鼠中,PS-MP暴露导致子宫受体受损和缺陷植入.
- 在肠道中观察到PS-MPs的积累.
- 检测到肠道微生物群结构和功能的显著变化,Alistipes和ACSL基因的增加.
- 铁灭菌激活的证据,由增加的MDA水平和与铁灭菌相关的蛋白质表明.
结论:
- 口服暴露于微塑料会损害女性的生殖健康,特别是子宫的受容性和植入.
- 肠道微生物群失生症在微塑料诱导的生殖毒性中起着至关重要的作用.
- 铁亡是微塑料诱导的生殖功能障碍的关键机制.
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