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在治疗晚期抑郁症的电治疗期间的混乱状态:前性队列研究

Thomas C Feenstra^1,2, Nathalie Denayer³, Kristof Vansteelandt³

¹GGZ Centraal Mental Health Care, Amersfoort, the Netherlands.

Acta psychiatrica Scandinavica

|March 18, 2025

概括

在患有抑郁症的老年人中,在电疗法 (ECT) 期间,混乱状态很常见,影响超过一半的患者. 这些异质状态,包括后触动动和长时间的迷失方向,可以在ECT治疗期间的任何时候发生.

科学领域:

老年精神病学是一门精神病学专业.
神经科学是一个神经科学.
临床心理学临床心理学

背景情况:

电疗法 (ECT) 是对严重抑郁症的有效治疗方法,特别是在老年人中.
虽然记忆丧失等认知副作用的记录很好,但在ECT期间的 (亚) 急性混乱状态在这个人群中不太了解.
患有抑郁症的老年人代表了一个脆弱的群体,理解ECT诱导的认知变化至关重要.

研究的目的:

调查电治疗 (ECT) 期间各种类型的混状态的发生率,复发率,并发率和临床过程.
专门检查这些困惑状态在老年人 (≥55岁) 诊断有重大抑郁症.
在晚年抑郁症队列中提供这些不良事件的全面描述.

主要方法:

前性队列研究 (RECALL) 包括145名老年人 (≥55岁) 患有重度抑郁症,正在接受ECT.
混状态子类型的评估:后视点和间视点妄想 (PID/IID),后视点动荡 (PIA),重定位时间延长 (TRO) 和亚急性认知衰退.
在整个ECT治疗过程中收集的数据.

主要成果:

超过一半 (55.9%) 的老年人在ECT期间经历了至少一种混乱状态亚型.
后动 (PIA) 和延长时间转向 (TRO) 是最常见的亚型.
间歇性妄想和延长的TRO出现高复发率 (分别为66.7%和50.0%);18.0%的人患有多种亚型.

结论:

在患有抑郁症的老年人中,在ECT期间,混乱状态非常普遍和异质.
这些状态可以在ECT过程中的任何时候出现,并表现出不同的复发模式.
需要进一步的研究来区分 (亚) 急性混状态,因为目前的评估工具可能不完全适合于ECT环境.

关键词:

认知方面的副作用.混国家混国家电疗法 (ECT) 是一种电疗法.晚年抑郁症 (LLD) 是一种疾病.一个主要的抑郁情节.

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