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Updated: Jul 17, 2026

In Vitro Analysis of E3 Ubiquitin Ligase Function
06:06

In Vitro Analysis of E3 Ubiquitin Ligase Function

Published on: May 14, 2021

通过阻碍信号动机的膜封存,激发LAG3免疫检查点功能

Yong Jiang1, Anran Dai2, Yuwei Huang3

  • 1School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; Key Laboratory of Multi-Cell Systems, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China.

Cell
|March 18, 2025
PubMed
概括

淋巴细胞激活基因3 (LAG3) 通过非K48结合的多基因激活,从而增强其免疫抑制. 这种由治疗抗体向的机制为癌症免疫治疗提供了新的策略.

关键词:
Cbl-b 在地方行动组3TCR 信号提供c-Cbl 其他癌症免疫疗法检查点无处不在

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