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微生物生产的免疫调节胆酸代谢物控制中枢神经系统的自身免疫力

Martina Antonini Cencicchio¹, Federico Montini², Vittoria Palmieri¹

¹Autoimmune Pathogenesis Unit, IRCCS San Raffaele Scientific Institute, 20132 Milan Italy.

Cell reports. Medicine

|March 18, 2025

概括

在多发性硬化症 (MS) 患者中,产生特定胆汁酸 (DCA,LCA) 的肠道细菌减少. 补充这些胆酸可以通过调节免疫细胞来预防中枢神经系统自身免疫.

科学领域:

免疫学免疫学免疫学
微生物学微生物学
神经科学是一个神经科学.

背景情况:

综合性肠道微生物群影响诸如多发性硬化症 (MS) 这样的自身免疫性疾病.
二级胆酸 (BAMs),如脱氧胆酸 (DCA) 和石胆酸 (LCA),调节免疫反应.
BAMs促进调节性T (Treg) 细胞,同时抑制Th17细胞.

研究的目的:

调查肠道微生物群衍生BAMs在MS病变发生过程中的作用.
确定降低DCA和LCA水平对MS患者免疫失调的影响.

主要方法:

在MS患者中分析肠道细菌组成和BAM度.
使用实验性自身免疫脑膜炎 (EAE) 的小鼠模型进行临床前验证.
用DCA/LCA来评估对Th17细胞分化和T细胞表型的影响.

主要成果:

产生二次BAM的细菌在MS患者的肠道微生物群中代表性不足.
多发性硬化症患者表现出肠道DCA和LCA水平的降低,与免疫失调和Th17细胞增加相关.
在临床前MS模型中,DCA/LCA的使用防止了EAE的发展.

结论:

免疫调节BAMs (DCA,LCA) 的降低水平有助于MS中枢神经系统自身免疫.
针对BAMs代表了预防和治疗MS的潜在治疗策略.

关键词:

在FoxP3+ Treg细胞中.辅助性T细胞17细胞胆酸代谢物的胆酸代谢物.代谢生物组的代谢生物组微生物组是一个微生物组.多发性硬化症多发性硬化症

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