Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关实验视频

Updated: May 21, 2025

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels
07:49

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Published on: January 14, 2021

3.4K

以血管网络为灵感的扩散性支架,用于设计功能性中脑器官.

Hongwei Cai1, Chunhui Tian1, Lei Chen1

  • 1Department of Intelligent Systems Engineering, Indiana University Bloomington, Bloomington, IN 47405, USA.

Cell stem cell
|March 18, 2025
PubMed

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Screening and diagnosis tools for sarcopenia: an overview of systematic reviews.

Systematic reviews·2026
Same author

Author Correction: Acoustic metamaterials-driven transdermal drug delivery for rapid and on-demand management of acute disease.

Nature communications·2026
Same author

Associations between lipid metabolism-related inflammation and obstructive sleep apnea risk and severity.

Sleep medicine·2026
Same author

The Evolving Landscape of Clinical Aging Clocks: From Epigenetic to Multi-Omics Integration.

Aging cell·2026
Same author

SLC16A1 Activates the STAT3/SLC7A11 Pathway to Mediate Ferroptosis Resistance and Tumor Progression in Head and Neck Squamous Cell Carcinoma.

Oncology research·2026
Same author

Organoid Brain-Machine-Interface Devices for Central Nervous System Repair.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
概括

血管网络启发的扩散性支架通过模仿生理扩散来改善器官功能,减少死亡和缺氧,以便更好地研究药物反应.

科学领域:

  • 生物技术是生物技术.
  • 发育生物学 发展生物学
  • 神经科学是一个神经科学.

背景情况:

  • 来自干细胞的器官在各种领域都有潜力,但在营养和氧气扩散方面存在局限性.
  • 特别是神经器官,由于扩散不良,因此遭受功能和表型限制.

研究的目的:

  • 开发和评估血管网络启发的扩散性 (VID) 支架,用于增强的有机体工程.
  • 提高有机体,特别是神经有机体的生理相关性和药物反应表型.

主要方法:

  • 3D打印网状管状通道网络 (VID支架),以模仿生理扩散.
  • 在标准井板中使用VID脚手架设计人类中脑器官.
  • 将人工有机体与常规有机体进行比较,以对死亡,缺氧和生理特征进行比较.

主要成果:

  • 视频支架成功设计了人类中脑有机体,其死亡和缺氧最小.
  • 工程器官体表现出增强的中脑特异性身份,氧化代谢,神经元成熟和网络活动.
  • 与常规器官相比,使用VID支架设计的器官显示了对芬太尼的药理反应的改进回顾.

结论:

  • VID支架克服了有机体培养中的扩散限制,使得产生更具功能性和生理相关的有机体成为可能.
关键词:
扩散扩散是一种扩散.药物反应药物反应电力生理学 电力生理学有机生物有机物perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion perfusion 这是一个非常重要的方法,它可以让一个人觉得自己是个好的人,而不是一个好的人,而是一个好的人.脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚手架,脚架,脚手架,脚手架,脚手架.血管网络是一种血管网络.

更多相关视频

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement
04:41

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement

Published on: December 13, 2024

1.5K
Micropatterning and Assembly of 3D Microvessels
13:05

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

11.7K

相关实验视频

Last Updated: May 21, 2025

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels
07:49

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Published on: January 14, 2021

3.4K
Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement
04:41

Author Spotlight: Improving Reproducibility in Vascular Organoids Using ROCK Inhibitors and Microwell Confinement

Published on: December 13, 2024

1.5K
Micropatterning and Assembly of 3D Microvessels
13:05

Micropatterning and Assembly of 3D Microvessels

Published on: September 9, 2016

11.7K
  • 这个平台增强了有机物药物反应表型,为治疗创新和发育生物学研究提供了一个有前途的工具.