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Louis Vande Perre¹, Javier Chávez Cerda², Soizic Gochard³

¹Bio-, Electro, and Mechanical, Systems (BEAMS), Université libre de Bruxelles, Brussels, Belgium; Service Opera-Photonique, Université libre de Bruxelles, Brussels, Belgium.

Journal of neuroscience methods

|March 18, 2025

概括

红外神经刺激 (INS) 可能首先激活较小的神经纤维,与电刺激 (ES) 不同. 这一发现为神经调节疗法提供了新的可能性,通过选择性地准特定的神经纤维类型.

科学领域:

神经科学是一个神经科学.
生物医学工程生物医学工程
生物物理学的生物物理.

背景情况:

红外神经刺激 (INS) 是一种使用光脉冲激活神经的新兴技术.
与电刺激 (ES) 不同,它通常首先激活大直径纤维,INS显示出偏好激活小直径纤维的潜力.
这种差异激活可能对各种临床神经调节应用非常有益.

研究的目的:

为了研究红外神经刺激 (INS) 的神经纤维类型选择性.
为了比较INS的纤维激活特征与传统的电刺激 (ES).
评估使用传导速度 (CV) 测量以区分INS激活的纤维类型的可行性.

主要方法:

使用1470nm二极管激光用于红外神经刺激 (INS).
在老鼠的坐骨神经和山羊的迷走神经上进行了传导速度 (CV) 测量.
将INS和ES之间的CV数据进行比较,以确定激活神经纤维群体的差异.

主要成果:

在老鼠的坐骨神经中,ES激活的纤维表现出明显更高的CVs (9.81 ± 3.18 m/s) 与INS激活的纤维 (8.10 ± 2.82 m/s) 相比.
在山羊迷走神经中,ES的平均CV值为6.47 ± 1.25 m/s.
像山羊迷走神经这样的大神经中的INS存在挑战,没有明显区分的复合神经动作潜力.

结论:

这些发现表明,红外神经刺激 (INS) 可能优先激活直径较小的神经纤维.
导电速度 (CV) 测量是评估INS纤维选择性的可行方法.
这种优先激活为开发有针对性的神经调节疗法提供了有希望的见解.

关键词:

复合神经动作潜力是一种神经动作潜力.导电速度是指导的速度.红外神经刺激红外神经刺激羊 ex vivo 迷走神经羊迷走神经鼠的 ex vivo 坐骨神经.

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