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休息状态大脑网络分离与老年人的步行速度和工作记忆有关

Sumire D Sato¹, Valay A Shah¹, Tyler Fettrow²

¹Department of Applied Kinesiology and Physiology, University of Florida, Gainesville, FL, USA.

|March 18, 2025

概括

老年人中较高的大脑网络分离与更好的身体功能和更快的步行速度有关,而不仅仅是年龄. 这突显了大脑的连接性.

科学领域:

神经科学是一个神经科学.
老年学是一门学科.
人类运动科学科学人类运动科学

背景情况:

与年轻人相比,老年人在行走和认知能力方面表现出更大的变化.
了解老化中的大脑连接差异对于识别功能衰退和弹性机制至关重要.

研究的目的:

为了比较年轻成年人和高功能和低功能老年人的大脑网络隔离.
在这些群体中调查大脑网络分离与工作记忆/行走功能之间的关联.

主要方法:

对21名年轻人和81名老年人的结构和功能静止状态MRI数据的分析.
将老年人分为高 (n=27) 和低 (n=54) 的身体功能组.
评估工作记忆 (列表排序) 和步行速度 (400米步行测试).

主要成果:

与功能较低的老年人相比,在高功能老年人中观察到传感运动和前庭网络中的更高的网络分离.
网络隔离与工作记忆和步行速度有显著的关联.
特定的网络隔离模式与增强的工作记忆和更快的步行速度相关.

结论:

大脑网络分离,特别是在与流动性相关的网络中,与老年人的身体功能有关.
更高的网络隔离与更好的身体功能和认知表现有关,不仅仅是独立于年龄.
这些发现为功能衰老和弹性的神经基础提供了洞察力.

关键词:

衰老的衰老衰老的衰老行为行为行为.功能连接性的功能连接性.休息状态休息状态分离隔离的隔离功能磁力共振成像 (fMRI) 是一种功能共振成像.

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