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胰岛素敏感性对食物暗示的影响在儿童中唤起了功能性大脑连接

Lorenzo Semeia¹, Ralf Veit², Sixiu Zhao²

¹Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany; German Center for Diabetes Research (DZD), Tübingen, Germany; Graduate Training Centre of Neuroscience, International Max Planck Research School, Tübingen, Germany.

|March 18, 2025

概括

胰岛素敏感性较低的儿童显示大脑与食物线索的连接发生了变化,这可能会影响饮食行为和未来糖尿病风险. 这些神经差异在岛屿功能连接中被观察到.

科学领域:

神经科学是一个神经科学.
代谢健康代谢健康
儿科研究儿科研究

背景情况:

儿童胰岛素抵抗是2型糖尿病和其他健康问题的风险因素.
成人研究将胰岛素耐药性与影响行为和代谢控制的改变大脑活动联系起来.
没有先前的研究探讨了与儿童胰岛素敏感性相关的食物暗示暴露期间的大脑连接.

研究的目的:

为了研究外周胰岛素敏感性和大脑功能连接性之间的关系,以应对儿童的食物线索.
为了确定不同程度的胰岛素敏感度的儿童之间对食物线索的神经反应的差异.

主要方法:

功能磁共振成像 (fMRI) 评估了53名儿童 (7-11岁) 在摄入葡萄糖之前和之后的脑反应.
通过口服葡萄糖耐受性测试 (oGTT) 估计了外围胰岛素敏感性.
基于任务的活动和功能连接 (FC) 被比较为较低和较高的胰岛素敏感性 (ISI) 的儿童,调整为年龄和BMIz.

主要成果:

患有较低ISI的儿童表现出较高的前部斜角-尾部FC和较低的后部斜角-中部皮层FC,而不论是食状态.
观察到岛屿FC的性别差异,受食状态和胰岛素敏感性的影响.
在对食物线索的平均大脑反应中没有发现显著差异.

结论:

患有较低外周胰岛素敏感度的儿童在对食物线索的反应中显示出不同的神经连接模式,特别是在胰岛内.
这些改变的大脑功能连接可能会影响饮食行为.
研究结果表明,这对了解儿童未来糖尿病风险有潜在的影响.

关键词:

孩子孩子孩子孩子食物提示符食物提示符功能连接性的功能连接性.胰岛素敏感性的原因肥胖问题肥胖问题功能磁力共振成像 (fMRI) 是一种

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