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通过多种传递路径评估AAV转导效率:从外周和中枢神经系统分析的见解

Na Kyung Lee1, Duk L Na2, Jong-Wan Kim3

  • 1Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, 06355, Republic of Korea; Cell and Gene Therapy Institute (CGTI), Research Institute for Future Medicine, Samsung Medical Center, 06351, Republic of Korea.

Neuroscience
|March 18, 2025
PubMed
概括

脑内 (ICV) 腺相关病毒9型血清 (AAV9) 传递有效地准中枢神经系统 (CNS). 静脉内 (IV) 和动脉内 (IA) 路径显示更广泛的分布,突出了基因治疗的路径选择.

关键词:
亚第诺相关病毒载体.中枢神经系统中枢神经系统基因治疗是一种基因疗法.动脉内部的动脉内.在脑内,脑室内内.静脉内输入 静脉内输入

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Spinal Cord: Information Processing01:10

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The spinal cord is an integral hub for motor and sensory information that enables the brain to communicate with the peripheral nervous system (PNS). This communication consists of relaying sensory data and transmission of motor commands.
Sensory Information Processing
Sensory information processing begins at the sensory receptors located in the skin and other tissues, which detect somatic sensory stimuli such as touch, temperature, or pain. These receptors function as catalysts, initiating...