在阿尔茨海默氏病连续体中,百叶状物量化和粉状物PET扫描视觉解释之间的一致性
Mohammad Khalafi1, Seyed Hani Hojjati1, Xiuyuan H Wang1
1From the Department of Radiology (MK., SHH., XHW., LZ., YL., TAB., QRR., EBT., SP., LG., NSF., MDL., GCC.), and Department of Neurology (ASN., SP.), Weill Cornell Medical Center, New York, NY, United States.
AJNR. American journal of neuroradiology
|March 18, 2025
概括
百化物 (CL) 尺度显示高一致性与视觉解释,用于评估在阿尔茨海默病 (AD) 的beta-amyloid (Aβ) PET扫描. 结合这两种方法,可以全面评估Aβ沉积的情况.
科学领域:
- 神经成像是一种神经成像.
- 阿尔茨海默氏症疾病研究研究
- 生物标志物量化量化
背景情况:
- 精确检测大脑β-粉样蛋白 (Aβ) 积累对于阿尔茨海默病 (AD) 诊断和治疗资格至关重要.
- 百叶状 (CL) 尺度标准化了Aβ正子发射断层扫描 (PET) 量化在不同的标志物和研究场所.
研究的目的:
- 评估百叶状体 (CL) 量化和Aβ PET扫描视觉解释之间的一致性.
- 在认知障碍 (CI) 和认知正常 (CU) 个体中评估这种一致性.
主要方法:
- 分析了221名参与者的247张AβPET扫描 (157张使用[11C]匹兹堡化合物B和90张使用[18F]Florbetaben).
- 标准化吸收值比率 (SUVRs) 用全球阿尔茨海默病协会交互网络 (GAAIN) 的指导方针转换为CL尺度.
- 百分比一致性和kappa统计评估了CL值和Aβ阳性视觉解释之间的一致性.
主要成果:
- 最高的整体一致性为93%,CL截止值为18 (kappa=0.84).
- 符合性因标记物而异,在CL 24显示97%的[18F]Florbetaben和在CL 18显示94%的[11C]Pittsburgh Compound B.
- 阴性 (98%) 比阳性 (90%) Aβ PET病例的一致性更高,在CI (96%) 与CU (93%) 参与者中略高.
结论:
- 对AβPET扫描的全球百叶状体 (CL) 量化显示了与视觉解释的高度一致性.
- 差异往往涉及焦点Aβ阳性在视觉审查不满足全球CL值.
- 整合CL量化和视觉评估可以提高对大脑Aβ沉积的评估.
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