羊膜切割和胎儿丧失的风险在双胞胎怀孕:一个病例对照研究
Sofia Roero1, Agata Ingala1, Silvana Arduino1
1Gynaecology and Obstetrics 2U, Sant'Anna Hospital, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, University of Turin, Turin, Italy.
Prenatal diagnosis
|March 18, 2025
概括
在双胞胎怀孕中,二-二 (DCDA) 双胞胎怀孕中的乳液切割不会增加胎儿丧失的风险. 这项研究发现,双胞胎接受羊切开术和没有接受羊切开术的双胞胎之间的胎儿损失率没有显著差异.
科学领域:
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 产前诊断 在产前诊断
- 双胞胎怀孕 双胞胎怀孕
背景情况:
- 有限的数据存在于与双胞胎怀孕的侵入性产前诊断相关的胎儿损失风险.
- 双胞胎双胞胎 (DCDA) 双胞胎占双胞胎妊娠的很大一部分.
研究的目的:
- 在没有并发症的DCDA双胞胎怀孕中,评估羊膜切开后胎儿损失的风险.
- 为了比较DCDA双胞胎进行羊膜切割和对照组之间的与手术相关的胎儿损失率.
主要方法:
- 追溯观察病例控制研究设计.
- 包括从2010年1月到2023年12月接受乳房膜切割的DCDA双胞胎怀孕 (病例组) 和没有接受乳房膜切割的双胞胎怀孕 (对照组).
- 主要结局:与手术相关的胎儿损失;次要结局:流产,整体胎儿损失和出生时的妊娠年龄.
主要成果:
- 在病例和对照组之间,一个胎儿 (0.9% vs 1.1%) 或两个胎儿 (0.5% vs 0.5%) 的与手术相关的胎儿损失没有显著差异.
- 在二次结果中没有显著差异,包括整体胎儿损失率.
- 多变量分析证实,乳液化对胎儿丧失风险没有显著影响.
结论:
- 胚胎切似乎不会在没有并发症的DCDA双胞胎怀孕中增加胎儿损失的风险,超过固有的基线风险.
- 研究结果表明,在这个特定的双胞胎群体中,该程序对于胎儿损失是安全的.
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