新生儿用德克斯梅德托米丁:新生儿重症监护病房的使用趋势和安全概况
Gozdem Kayki1, Nadir Yalcin2,3, Hasan Tolga Celik4
1Department of Pediatrics, Division of Neonatology, Hacettepe University Faculty of Medicine, Ankara, Turkey gozdem.kayki@hacettepe.edu.tr.
BMJ paediatrics open
|March 18, 2025
概括
新生儿重症监护室 (NICU) 的德克斯梅德托米丁使用量有所增加,较高的剂量和更长的持续时间显示急性期间不增加药物不良反应 (ADRs).
科学领域:
- 新生儿重症监护室新生儿重症监护室
- 药理学 药理学是指药理学的学科.
- 儿科重症监护 儿科重症监护 儿科重症监护
背景情况:
- 德克斯梅德托米丁是一种α-2上腺激动剂,具有镇静剂,焦虑缓解剂和止痛作用.
- 它在新生儿重症监护室 (NICU) 的应用在过去十年中出现了显著的增长.
- 这项研究旨在评估德克斯梅德米丁在NICU中的安全性和使用趋势.
研究的目的:
- 评估德克斯梅德托米丁在NICU患者中的安全性.
- 为了识别随着时间的推移,德克斯梅德托米丁的利用趋势.
- 调查德克斯梅德托米丁剂量,治疗持续时间和药物不良反应之间的关系.
主要方法:
- 从2018年到2023年,在土耳其的IV级NICU中进行了一项回顾性观察研究.
- 分析了383名接受连续德克斯梅德托米丁输注的患者的数据.
- 统计分析,包括曼-惠特尼U,千二测试和回归分析,用于比较群体并确定影响因素.
主要成果:
- 德克斯梅德托米丁最常见的适用于术后疼痛管理 (81.5%).
- 在研究期间,观察到初始剂量和治疗持续时间的显著增加.
- 药物不良反应 (ADRs),主要是心肌梗塞,发生在5%的患者中,与剂量,持续时间或妊娠年龄无关.
结论:
- 在NICU中使用德克斯梅德托米丁在剂量和持续时间方面显著增加.
- 较高剂量和延长德克斯梅德托米丁治疗时间与急性药物不良反应发生率的增加无关.
- 这些发现支持在新生儿群体中继续评估德克斯梅德托米丁的安全性.
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