在韩国成年人中,残留胆固醇和心血管和全因死亡率
Byung Jin Kim1, Mi Yeon Lee2, Eun Hye Cho3
1Division of Cardiology, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea (Dr Kim).
Journal of clinical lipidology
|March 18, 2025
概括
高剩余胆固醇 (RC) 水平与韩国成年人心血管和全因死亡率的增加有关. 升高的RC,特别是高hsCRP或脂蛋白 (a),显著增加心血管死亡风险.
科学领域:
- 心血管健康 心血管健康
- 脂质代谢 脂质代谢是什么
- 死亡风险评估 死亡风险评估
背景情况:
- 关于非西方人口的残留胆固醇 (RC) 和死亡率的研究有限.
- 之前的研究主要集中在西方群体,需要对不同种族群体进行研究.
研究的目的:
- 调查残留胆固醇 (RC) 与死亡结果之间的关联.
- 为了评估年轻到中年韩国人口中的这些风险.
主要方法:
- 来自康三星健康研究 (2003-2016) 的268219名参与者 (平均年龄38岁) 的队列研究.
- 剩余胆固醇 (RC) 计算为: 总胆固醇 - LDL-C - HDL-C.
- 平均随访时间为6.7年.
主要成果:
- 较高的RC水平与心血管和全因死亡率的增加相关.
- 在RC的最高五分位数中,心血管死亡率的危险比率显著增加.
- 在RC和癌症死亡率之间没有发现显著的关联.
结论:
- 高剩余胆固醇 (RC) 是心血管和全因死亡的一个重要风险因素.
- 高RC与高敏感性C反应蛋白 (hsCRP) 或高脂蛋白 (a) 的结合显著增加了心血管死亡风险.
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