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在脊椎关节炎中评估外周关节炎的仪器的评估:对ASAS-PerSpA研究的分析

Dafne Capelusnik¹, Clementina Lopez-Medina², Désirée van der Heijde³

¹Care and Public Health Research Institute (CAPHRI), Maastricht University, Maastricht, The Netherlands; Department of Rheumatology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel.

Annals of the rheumatic diseases

|March 18, 2025

概括

脊椎关节炎 (SpA) 中外周关节炎的疾病活动仪表显示出良好的构造有效性. 像DAS28和DAPSA这样的复合得分最好区分活跃疾病和非活跃疾病.

科学领域:

类风湿病学类风湿病学
临床评估临床评估
脊椎关节炎研究研究

背景情况:

周围关节炎是脊椎关节炎 (SpA) 的一个关键表现.
准确评估疾病活动对于有效管理SpA至关重要.
在SPA中对外周关节炎的现有仪器需要对构造有效性和辨别能力进行验证.

研究的目的:

评估SPA中外围关节炎当前疾病活动仪器的构造有效性.
评估这些工具在区分活跃与非活跃疾病状态时的已知群体歧视能力.

主要方法:

来自ASAS-PerSpA研究的数据分析,包括4121名患有轴性SPA,外周SPA或牛皮关节炎 (PsA) 的患者.
评估的工具包括患者全球评估 (PGA),各种疾病活动指数 (BASDAI,ASDAS,DAPSA,DAS28,DAS44),关节计数 (SJC,Tender Joint Count) 和CRP.
构造有效性通过与外部构造的相关性进行评估;基于PGA和SJC标准使用标准化平均差异 (SMD) 分析已知的组歧视.

主要成果:

所有评估的仪器都显示出出色的构造有效性,100%的假设通过与外部措施的相关性得到证实.
除CRP外,大多数仪器都显示出已知的群体歧视 (SMD≥0.8),其中DAS28和DAPSA表现出最高的歧视力.
结合关节计数的综合评分在不同SPA表型中更好地区分活跃和非活跃的疾病.

结论:

在SPA中对外围关节炎的所有评估疾病活动仪表都表现出良好的构造有效性和辨别能力.
复合得分,特别是DAS28和DAPSA,显示出在SPA患者的活跃和不活跃疾病状态之间区分的卓越能力.

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